AUGMENTIN is an oral antibacterial combination consisting of the semisynthetic antibiotic amoxicillin and the β-lactamase inhibitor, clavulanate potassium.
Clavulanate potassium possesses the ability to inactivate a wide variety of β-lactamases by blocking the active sites of these enzymes.
Augmentin is an antibiotic with a broad spectrumof bactericidal activity against many gram-positive and gram-negative bacteria.
Gram- positive bacteria: Staphylococcus aureus, Staphylococcus saprophyticus, Streptococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, anaerobi: Closridium spp., Peptostreptococcus spp.
Gram – negative bacteria: Escherichia coli, Haemophilus influenzae, Klebsiella species, Moraxella catarrhalis, Enterobacter species, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Legionella species; anaerobe: Bacteroides species and bacteroides fragilis inclusive.
- This drug is usually supposed to be taken regularly, every 8 hours with some food, although the recommendations of your health care provider may be slightly different from this routine. Make sure you take the drug at the same time every day – this way you will remember to take it and will benefit from the treatment, as the drug will be at the same level in your bloodstream. If you have been prescribed the liquid form, make sure you shake it well before using. Chewable tablets should not be swallowed whole – make sure you chew them properly and have a drink of water after you swallow the tablet to make sure the entire dosage gets into your stomach. Take the medicine prescribed for as long as your health care provider recommended. You may feel better after taking it for a short period of time – but that does not mean the conditions has been treated completely. Stropping the treatment before you are told so may cause the bacteria to continue multiplying and become resistant to this drug. A relapse of infection is dangerous – so make sure you follow all the instructions on the label or those provided by your doctor.
- Contraindications and cautions:
Augmentin is contraindicated to patients with a history of allergic reactions to any penicillin, infectious mononucleosis, lymphatic leukemia.
Augmentin is active in infections caused by Streptococci, staphylococci, gonococcus, mycoplasm, etc.
It is assimilated and absorbed well by the organism. It doesn’t irritate the path of gastrointestinal mucous membrane. It is stable in the presence of gastric acid.
Indications: Angina, Otitis media, acute and chronic bronchitis, pneumonia, pneumonia, cysts, gonorrhea, stomach ulcers and stomach cancer, cholecystitis, dental infection.
Probenecid decreases the renal tubular secretion of amoxicillin. Do not combine it with disulfiram. Combination is incompatible with the aminoglucosides. Augmentin increases the effect of anticoagulants.
- Method of application:
Adults and children: the dose is 375mg tablet of augmentin 3 times daily, in severe infections – 625mg 3 times daily.
- Oral Suspension:
- babies: ½.............teaspoonful 3 times daily;
- Children 1-7 years old: one teaspoonful 3 times daily;
- Children 7-14 years old: two teaspoonfuls 3 times daily.
- Drops: babies: 0, 75-1, 25 ml.
- In severe infections augmentin is used as intravenous infusion:
- Adults and children up to 12 years old - 1,2g every 8 hours;
- Children from 3 months to 12 years old - 30mg/kg;
- 3 months premature newborns and those who belong to the perinatal life take 30mg/kg every 12 hours.
The duration of treatment is 5-14 days
In case of overdose the patient can have an attempt at emesis, nausea and diarrhea.
The treatment: symptomatic therapy. In severe infections hemodialysis is carried out.
- Overdose symptoms are not expected to be life-threatening, but you still need to report them to your local emergency center. The following ones are supposed to be reported: stomach pain, vomiting, diarrhea, rash, hyperactivity, and drowsiness. Seek medical assistance for yourself or another person that seems to have taken too much of Augmentin to prevent the side effects from getting even worse.
- Special precautions:
While Augmentin possesses the characteristic low toxicity of the penicillin group of antibiotics, periodic assessment of organ system functions, including renal, hepatic, and hematopoietic function, is advisable during prolonged therapy. Augmentin is also indicated in patients allergic to penicillin and cephalosporin.
- Side effects:
Following overdosage, patients have experienced primarily gastrointestinal symptoms including stomach and abdominal pain, vomiting, and diarrhea. The most frequently reported adverse effects were diarrhea/loose stools, nausea, skin rashes and urticaria, vomiting and vaginitis. Anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura.
Augmentin serious side effects are rare and unlikely to occur. However, you need to report them to your health care provider in case they do appear. The following ones are considered to be serious enough to be reported: severe skin rash, itching, hives, difficulty breathing, wheezing, vaginal itching, yellowing of the skin or eyes, and any other ones that make you feel miserable or prevent you from doing your regular activities. Less serious side effects are more likely and can include diarrhea, upset stomach, vomiting, and mild skin rash. You do not need to report mild side effects just as you get them, as in most cases no special treatment is required. However, if the side effects that were originally mild change in intensity and start to bother you way too much – they need to be reported to see if the dosage prescribed is too high for you.
- Things to discuss with your doctor before you take Augmentin
In case you are allergic to any of the following drugs, make sure you do not start taking Augmentin: penicillin, amoxicillin, clavulanic acid, or cephalosporins (a class of drugs). Allopurinol and probenecid are not supposed to be combined with Augmentin without your doctor's consent. If you are taking these medications, your health care provider may want to change your dosage to make sure you will benefit from the treatment as much as possible. Make sure you share with your doctor any information that may be of importance when prescribing a certain dosage – for example, your medical conditions. The following ones are supposed to be reported: kidney or liver disease, asthma, hay fever, mononucleosis, allergies, and hives.
- Augmentin in pregnant women
Although this drug is FDA pregnancy B, it may still pass into your breast milk. If you intend to breastfeed – make sure your health care provider is aware of that fact. This drug can make your birth control pills less effective. Make sure you use an additional contraceptive (discuss its effectiveness with your doctor beforehand) or abstain from having sex during the period of your treatment.
Augmentin is effective against many different bacteria including streptococci, staphylococci, gonococci, mycoplasma, clamydia and others. It is well for body tolerance. It does not irritate mucous membrane of gastrointestinal tract. It is stable in gastric juice. Augmentin is well absorbed in.