It is a second-generation cephalosporin antibiotic for oral administration. Cefaclor has been shown to be active against most strains of the following microorganisms: Staphylococci, Streptococcus pneumoniae, Streptococcus pyogenes, Moraxella catarrhalis, Haemophilus influenzae, including ß-lactamase-producing ampicillin-resistant strains, Klebsiella spp, Proteus mirabilis, Citrobacter diversus, Neisseria gonorrhoeae, Peptococci, Peptostreptococci, Propionibacterium acnes.
- Contraindications and cautions:
Cefaclor is contraindicated in patients with the detected allergy to the cephalosporin group of antibiotics.
Antibiotic with a broad spectrum effect.
It is a drug that is active against bacteria such as: staphylococcus, streptococcus, treponema and other microorganisms. It is assimilated well by the organism. It is stable in the presence of gastric acid.
Respiratory diseases are the indication to use (pharyngitis, Laryngitis, bronchitis, pneumonia), lymphadenitis pyelonephrit, cystitis, folliculin, furunculosis, mastitis and others.
Medoclor enhances the anticoagulant effect. The renal excretion of cefaclor is inhibited by probenecid (resulting in increased concentrations of drug in the blood plasma).
- Method of application:
Cefaclor is administered orally. The usual adult dosage is 250 mg 3 times daily. For more severe infections doses may be doubled. The usual recommended daily dosage for children is 20 mg/kg/day in 3 divided doses every 8 hours. In more serious infections and otitis media the doses may be doubled.
In case of overdose the patient can have an attempt at emesis, nausea and diarrhea. Treatment: absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal.
- Special precautions:
Cefaclor should be administered with caution in the presence of markedly impaired renal function, in individuals with a history of gastrointestinal disease, particularly colitis. Caution should be exercised when cefaclor is administered to a nursing woman.
- Side effects:
The principal side effect of the cephalosporins is hypersensitivity. Side effects that include gastrointestinal disturbances (e.g. diarrhea, nausea and vomiting, abdominal discomfort, disturbances in liver enzymes, transient hepatitis and cholestatic jaundice), headache, and Stevens-Johnson syndrome, leucopenia, agranulocytosis, aplastic anaemia and haemolytic anaemia.