Is a second-generation cephalosporin antibiotic. Cefuroxime has been demonstrated to be active against most strains of the following microorganisms: Staphylococcus aureus (including beta-lactamase–producing strains), Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Staphylococcus epidermidis, Proteus mirabilis, Providencia rettgeri. Most strains of Clostridium difficile and Bacteroides fragilis are resistant to cefuroxime. CEFTIN is a semisynthetic, broad-spectrum cephalosporin antibiotic for oral administration too.
- Contraindications and cautions:
Cefuroxime is contraindicated in patients with detected allergy to the cephalosporin group of antibiotics.
Antibiotic with a broad spectrum effect.
It is a drug that is active against bacteria such as: staphylococcus, streptococcus, treponema and other microorganisms. It is assimilated well by the organism. It is stable in the presence of gastric acid.
Respiratory diseases are the indication to use (pharyngitis, Laryngitis, bronchitis, pneumonia), lymphadenitis pyelonephrit, cystitis, folliculin, furunculosis, mastitis and others.
Concomitant administration of probenecid with cefuroxime axetil tablets increases the area under the serum concentration versus time.
- Method of application:
Adult’s dosage is 750-1500mg in 3 divided doses during 5-10 days; dosage for children up to 3 months is 50-100mg in 3-4 divided doses, in severe infections and meningitis the dosage is 200-240mg/kg/day in 3-4 divided doses, in uncomplicated Gonorrhea 1g in one dose.
Overdosage of cephalosporins can cause cerebral irritation leading to convulsions. Serum levels of cefuroxime can be reduced by hemodialysis and peritoneal dialysis.
- Special precautions:
Prolonged use may result in fungal or bacterial superinfection, including diarrhea and pseudomembranous colitis.
- Side effects:
Cefuroxime axetil is generally well tolerated and side effects are usually transient. Reported side effects include abdominal pain, diarrhea, dizziness, fatigue, headache, heartburn, loss of appetite, nausea, or vomiting, transient hepatitis disturbances in liver enzymes, leucopenia, aplastic anaemia and haemolytic anaemia or allergic reactions.