Drug combined with analgesic, antipyretic, decongestant and expectorant action. Paracetamol inhibits cyclooxygenaze and reduces prostaglandins synthesis, pain and temperature. Ascorbic acid compensates vitamin C loss that is characteristic for the incipient phases of acute respiratory infections. Phenylefrin contracts sanguine vessels and reduces congestion.
- Contraindications and cautions:
Hyper sensibility to any of the drug components, severe renal and hepatic affections, arterial hypertension, hyperthyrosis, diabetes and heart diseases.
Diseases provoked by cold, influenza.
Metoclopramide and Domperidone increase the effect of the drug.
- Method of application:
Adults and children over the age of 12 years, the contents of one package dissolving in a glass of hot water; dose can be repeated after 6-8 hours (but not more than four times a day).
In case of overdose the patients can have an attempt at emesis, nausea, anorexia and stomach upset. The treatment: gastric lavage and symptomatic therapy.
- Special precautions:
Caution should be exercised when Coldrex Hotrem is administered in pregnancy and lactation period.
- Side effects:
Allergic reactions (cutaneous eruption, angioneurotic edema, nettle rash). Arterial hypertension can appear rarely (cephalalgia, nausea, vomiting, diarrhea, insomnia, palpitations).