Analgesic/antipyretic with slight anti-inflammatory action. The action mechanism consists of the prostaglandins synthesis inhibition, predominant in the hypothalamic thermoregulation center.
- Contraindications and cautions:
Hyper sensibility to drug, severe hepatic and renal insufficiency, glaucoma, urine retention, blood diseases, pregnancy, lactation, age under 3 months.
Slight and moderate Algias: cephalalgia, odontalgia, myalgias, neuralgias, artralgias, primary dysmenorrhea, feverish conditions of diverse provenience.
Increases the hepatotoxic effect of barbiturates, antiepileptics, rifampicine, alcohol, and specific action of nesthyroidien anti-inflammatory, indirect anticoagulants. Acetilcysteine reduces adverse and toxic effects of paracetamol.
- Method of application:
Adults - 500-1000 mg 3 times per day , 30 min before eating, children (3 months-1 year) - 25-50 mg 2-4 times per day , 2-5 years old - 100-150 mg 2-4 times per day , 5-10 years old - up to 1000 mg/day, 10-15 years old - up to 1500 mg/day.
Drinkable suspension: children of 6-12 years 10-20 ml (2-4 teaspoons) 4 times per day, 1-6 years old 5-10 ml (1-2 teaspoons) 4 times per day, 3 months-1 year old 2,5-5 ml (1/2-1 teaspoon) 4 times per day . The duration of treatment is 10 days.
Hepatic insuficiency, methemoglobinemia. Treatment: gastric lavage; activated charcoal, acetylcysteine as antidote (initially 140 mg/kg, then 70 mg/kg each 4 hours for a period of a couple of days). In severe intoxication hemodialysis must be used. It is recommended to control the aminotransferasis level.
- Special precautions: Renal or hepatic insufficiency.
- Side effects:
Anemia, agranulocytosis, thrombocytopenia, and allergic reaction.